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Updated: Apr 15, 2026

Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

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Published on: October 29, 2019

Migrating intrathecal high-velocity projectile.

Yuen T C Chan¹, Rafid Al-Mahfoudh, Shymica Thennakon

¹a Department of Neurosurgery , The Walton Centre for Neurology and Neurosurgery NHS Trust , Liverpool , United Kingdom.

British Journal of Neurosurgery

|April 1, 2015

Summary

This summary is machine-generated.

Spinal gunshot injuries can lead to severe damage and neurological deficits. A case study reveals a migrating intrathecal bullet caused delayed neurological injury, highlighting the risks of delayed assessment and intervention.

Keywords:

bullet intrathecal migration projectile spine trauma

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Area of Science:

Neurosurgery
Trauma Surgery
Spinal Cord Injury Research

Background:

Spinal bullet injuries pose significant risks for neurological damage.
Intrathecal migration of projectiles can lead to delayed complications.
Early assessment of spinal trauma is crucial for patient outcomes.

Observation:

A patient sustained a gunshot injury to the spine.
The bullet migrated intrathecally within the spinal canal.
Initial assessment revealed no immediate neurological deficits.

Findings:

The intrathecal bullet migration led to the subsequent development of neurological deficits.
Delayed neurological sequelae resulted from the projectile's intraspinal movement.
The case illustrates a rare but serious complication of spinal gunshot wounds.

Implications:

Highlights the potential for delayed neurological deterioration in spinal bullet injuries.
Emphasizes the need for vigilant monitoring of patients with intrathecal projectiles.
Informs surgical strategies and follow-up protocols for spinal trauma cases involving migrating bullets.