[Experimental study on farmer's lung-like lesions caused by Beauveria bassiana]

113 lung specimens from rats and mice were observed under both LM and TEM, after inhalation of gonidiospores of Beauveria bassiana for 18 months 78.8% of the 113 cases developed chronic interstitial pneumonia (IP). There were desquamative pneumonitis mainly with macrophage; granuloma with multinucleate giant cells or fibrosis, and localized pulmonary edema. These lesions were firstly described to be caused by the spores here. It was considered that IF lesions might be related to types III, IV hypersensitivity reaction. The authors emphasized that these lesions might be similar to those observed in farmer's lung or extrinsic allergic alveolitis (EAA).