Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programmable and on-demand drug release using electrical stimulation.

Y T Yi1, J Y Sun1, Y W Lu2

  • 1Department of Chemical Engineering, National Taiwan University , Taipei, Taiwan, Republic of China.

Biomicrofluidics
|April 1, 2015
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinicopathological characteristics and prognostic significance of steatotic hepatocellular carcinoma with HBV-related cirrhosis: a propensity score-matched study].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same author

[Survey on current practices and awareness regarding analgesic and sedation management in pediatric intensive care units in China].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2026
Same author

Circular RNA eukaryotic translation initiation factor-6 motivates aerobic glycolysis and angiogenesis in triple negative breast cancer <i>via</i> performing as the competing endogenous RNA of microRNA-296-3p to target metallothionein 2A.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2025
Same author

[Targeting the root causes of hypertension: bridging mechanistic insights and clinical translation].

Zhonghua xin xue guan bing za zhi·2025
Same author

[A multicenter retrospective study on clinical features and pathogenic composition of septic shock in children].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2024
Same author

[Respiratory virus infection and its influence on outcome in children with septic shock].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2024
Same journal

Parallelized contactless microfluidic dispenser with superhydrophobic nozzles for scalable combinatorial screening.

Biomicrofluidics·2026
Same journal

Time resolved luminescence of millisecond lifetime dyes in droplet microfluidic systems.

Biomicrofluidics·2026
Same journal

Emerging trends in functional molecularly imprinted polymers for electrochemical detection of biomarkers.

Biomicrofluidics·2025
Same journal

Deep learning assisted mechanotyping of individual cells through repeated deformations and relaxations in undulating channels.

Biomicrofluidics·2025
Same journal

<i>Giardia</i> purification from fecal samples using rigid spiral inertial microfluidics.

Biomicrofluidics·2025
Same journal

Point of care sepsis diagnosis: Exploring microfluidic techniques for sample preparation, biomarker isolation, and detection.

Biomicrofluidics·2025
See all related articles

This study introduces an implantable device using electrical stimulation for on-demand drug delivery. It offers precise control over drug release rates and pulsatile delivery for targeted therapeutic applications.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Drug Delivery Systems

Background:

  • Microfabrication advancements enable sophisticated implantable drug delivery devices.
  • Current devices aim for precise administration and controlled release rates at specific locations.

Purpose of the Study:

  • To present a novel membrane-based drug delivery device.
  • To demonstrate electrically controlled, on-demand drug release with fast rates.

Main Methods:

  • A device was designed with hydrogels containing ionic model drugs in a reservoir separated by a membrane.
  • Electrokinetic forces were used to drive drug molecules out of the hydrogels.
  • Electrical stimulation via voltage adjustments controlled drug release profiles.

Related Experiment Videos

Main Results:

  • Release rates were electrically tunable by adjusting stimulated voltage.
  • Pulsatile drug release was achieved using square voltage waves, enabling rapid on/off switching.
  • Drug dose was determined by voltage duration and amplitude, allowing programmed release cycles.

Conclusions:

  • The developed device offers precise, on-demand, and pulsatile drug delivery.
  • Electrical control over release kinetics provides a versatile platform for targeted therapies.
  • This technology has potential for advanced implantable therapeutic systems.