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Updated: Apr 15, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
The impact of acute brucellosis on mean platelet volume and red blood cell distribution
Turhan Togan1, Huseyin Narci2, Hale Turan1
1Department of Infectious Diseases and Clinical Microbiology, Baskent University, Ankara, Turkey.
Background:
Brucellosis is an inflammatory disease which may infect any organs or systems in the body. Mean Platelet Volume (MPV) is one of the most frequently used surrogate markers of platelet function. It reveals the presence of disease activity in many inflammatory diseases. Red blood cell distribution width (RDW) is a parameter that measures variation in red blood cell size or red blood cell volume. Its predictive value approves inflammatory and infectious diseases.
Objectives:
The current study aimed to determine the assessment levels of red blood cell distribution in cases with acute brucellosis.
Patients And Methods:
The current study investigated whether MPV and RDW played any roles in acute brucellosis diagnosis. The study was conducted from 2008 to 2014 through prospective examination of the inflammatory markers found in adult patients with acute brucellosis.
Results:
The follow-up within the year after treatment was examined. The values of age, gender, leukocyte count, C-reactive protein, RDW and MPV were recorded. The study included 351 subjects, 250 of them in the acute brucellosis group and 101 in the control group. The mean MPV levels were 7.64 ± 1.30 fL, and 7.67 ± 1.29 fL in the acute brucellosis and control groups, respectively (P > 0.05). The mean CRP levels were 32.57 ± 53.20 mg/dL, and 4.81 ± 4.89 mg/dL in the acute brucellosis and control groups, respectively (P < 0.05). There was no statistically significant difference between the two groups regarding the RDW level and the mean leukocyte count (P > 0.05).
Conclusions:
While the CRP value was in patients with acute brucellosis in the current study, the MPV, RDW and leukocyte counts were within the normal range. CRP value remains the most valuable inflammatory marker in cases of acute brucellosis.
Insights
This study found that while C-reactive protein (CRP) levels were elevated in acute brucellosis patients, Mean Platelet Volume (MPV) and Red Blood Cell Distribution Width (RDW) were not reliable indicators for diagnosing this inflammatory disease.
Area of Science:
- Infectious Diseases
- Hematology
- Inflammatory Markers
Background:
- Brucellosis is a systemic inflammatory disease affecting various organs.
- Mean Platelet Volume (MPV) and Red Blood Cell Distribution Width (RDW) are explored as potential markers for inflammatory conditions.
- Their role in acute brucellosis diagnosis requires further investigation.
Purpose of the Study:
- To evaluate the diagnostic utility of MPV and RDW in acute brucellosis.
- To assess red blood cell distribution parameters in patients with acute brucellosis.
Main Methods:
- Prospective study conducted from 2008 to 2014.
- Included 351 adult subjects: 250 with acute brucellosis and 101 controls.
- Analyzed leukocyte count, C-reactive protein (CRP), RDW, and MPV levels.
Main Results:
- No statistically significant differences in MPV or RDW levels were observed between acute brucellosis patients and controls.
- Leukocyte counts also showed no significant difference between groups.
- C-reactive protein (CRP) levels were significantly higher in the acute brucellosis group (P < 0.05).
Conclusions:
- MPV, RDW, and leukocyte counts are not reliable indicators for diagnosing acute brucellosis.
- C-reactive protein (CRP) remains a valuable inflammatory marker for acute brucellosis.
- Further research may explore other hematological parameters in brucellosis.
