Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anorexia Nervosa01:28

Anorexia Nervosa

2.0K
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
2.0K
Bulimia Nervosa01:30

Bulimia Nervosa

1.1K
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
1.1K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

9.4K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
9.4K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

6.1K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
6.1K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

1.4K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiological correlates of interoception and the effect of heart rate variability biofeedback.

Frontiers in network physiology·2026
Same author

Erratum: Multivariate assessment of the central-cardiorespiratory network structure in neuropathological disease (2018<i>Physiol. Meas</i>.<b>39</b>074004).

Physiological measurement·2026
Same author

"Locked in my body, caught up in my mind": Neural signatures of body image rumination in anorexia nervosa.

Brain research bulletin·2026
Same author

Risk, reward, and suicide: how impulsivity and loss aversion influence decision-making in individuals who have attempted suicide.

Frontiers in psychiatry·2026
Same author

Central autonomic network-heart interplay in anorexia nervosa. A cross-spectral dynamic causal modeling study.

NeuroImage. Clinical·2026
Same author

Profound neuronal differences during exercise-induced hypoalgesia between athletes and non-athletes revealed by functional near-infrared spectroscopy.

The Journal of physiology·2026

Related Experiment Video

Updated: Apr 15, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.3K

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa.

Karl-Jürgen Bär1, Feliberto de la Cruz1, Sandy Berger1

  • 1Psychiatric Brain & Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.

Journal of Psychiatry & Neuroscience : JPN
|April 1, 2015
PubMed
Summary

Anorexia nervosa patients show structural and functional brain abnormalities in areas processing bodily sensations. These changes in the frontoparietal-cingulate network correlate with pain perception and illness severity.

More Related Videos

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

79.7K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.6K

Related Experiment Videos

Last Updated: Apr 15, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.3K
Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

79.7K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.6K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Anorexia nervosa (AN) is associated with distorted body image, potentially linked to dysfunction in specific brain regions.
  • Previous research suggests altered brain activity in AN patients, particularly in areas involved in pain processing.
  • A connection between structural changes in the frontoparietal-cingulate network and functional alterations during pain perception in AN is hypothesized.

Purpose of the Study:

  • To identify structural and functional brain abnormalities in patients with anorexia nervosa.
  • To investigate the relationship between these brain alterations, pain processing, and clinical characteristics in AN.

Main Methods:

  • Pain thresholds were assessed in AN patients and healthy controls.
  • Functional magnetic resonance imaging (fMRI) was used to measure brain activity during thermal pain stimulation.
  • Structural MRI data were analyzed using voxel-based morphometry and surface-based approaches to assess grey matter volume and cortical thickness.

Main Results:

  • Patients with anorexia nervosa exhibited significantly reduced grey matter volume and cortical thickness in the frontoparietal-cingulate network.
  • AN patients showed increased blood oxygen level-dependent (BOLD) signals in the midcingulate and posterior cingulate cortex during painful heat stimuli.
  • These functional changes positively correlated with increased pain thresholds, while structural reductions correlated with pain thresholds, symptom severity, and illness duration.

Conclusions:

  • The study confirms localized structural and functional brain abnormalities in AN patients within regions crucial for processing bodily stimuli.
  • The observed structural and functional deviations are associated with thermal pain perception and clinical features of AN.
  • These findings suggest a potential common neuronal origin for the observed brain abnormalities and clinical manifestations in anorexia nervosa.