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Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
A meta-analysis platform methodology for determining the comparative effectiveness of antihepatitis C virus regimens
Kristine R Broglio1, Eric S Daar, Melanie Quintana
1Berry Consultants, LLC, Austin, TX 78746, USA.
Aim:
Many hepatitis C virus regimens are unlikely to be compared head to head. In more difficult to treat populations where there is no standard of care, trials are single arm. We describe a flexible meta-analysis platform in this setting.
Methods:
Our meta-analysis is literature based. We illustrate our methodology and show how inference can be extended to single-arm trials.
Results:
As an example, in the single arm setting, a regimen with response rates of 84, 72 and 54% in genotype 1a across treatment naive, previous partial responders and previous null responders, respectively, would have 95% probability of superiority to IFN-α + RBV + TPV.
Conclusion:
This is a rigorous approach to comparative effectiveness that accounts for varying patient populations and plans for the incorporation of emerging treatments.
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