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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
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Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

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Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
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Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors01:13

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Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids01:31

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In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
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Related Experiment Video

Updated: Apr 15, 2026

Cooling or Warming the Esophagus to Reduce Esophageal Injury During Left Atrial Ablation in the Treatment of Atrial Fibrillation
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[Exfoliative esophagitis while taking dabigatran].

Wolfgang Scheppach1, Malte Meesmann2

  • 1Medizinische Klinik, Schwerpunkt Gastroenterologie / Rheumatologie.

Deutsche Medizinische Wochenschrift (1946)
|April 1, 2015
PubMed
Summary
This summary is machine-generated.

Dabigatran use in a 77-year-old woman was linked to exfoliative esophagitis, causing severe esophageal symptoms. Discontinuing the anticoagulant led to rapid symptom resolution and mucosal healing.

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Area of Science:

  • Gastroenterology
  • Pharmacology
  • Internal Medicine

Background:

  • A 77-year-old woman with atrial fibrillation and hypertension was treated with dabigatran.
  • Long-term anticoagulant therapy can present with various gastrointestinal side effects.

Observation:

  • The patient presented with severe chest pain, heartburn, dysphagia, and odynophagia.
  • Esophageal endoscopy revealed sloughing of mucosal casts in the upper esophagus.

Findings:

  • Discontinuation of dabigatran resulted in symptom resolution within 3 days.
  • Follow-up endoscopy confirmed complete healing of the esophageal mucosa after 12 days.

Implications:

  • Dabigatran intake may be associated with exfoliative esophagitis.
  • Prolonged drug contact could cause caustic tissue damage to the esophagus.
  • This case highlights a potential adverse effect of dabigatran on esophageal mucosa.