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Topical NSAIDs effect on corneal sensitivity.

Daniel D Singer1, John Kennedy, John R Wittpenn

  • 1*Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; †Ophthalmic Consultants of Long Island, East Setauket, NY; and ‡State University of New York at Stony Brook, Stony Brook, NY.

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|April 1, 2015
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Summary
This summary is machine-generated.

Topical nonsteroidal anti-inflammatory drugs (NSAIDs) provide anesthetic effects for ophthalmic use. All four currently available topical NSAIDs demonstrated similar anesthetic properties in a study of healthy volunteers.

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Topical nonsteroidal anti-inflammatory drugs (NSAIDs) are used for various eye conditions.
  • Previous research indicated anesthetic effects for branded diclofenac and ketorolac.

Purpose of the Study:

  • To evaluate the anesthetic effects of four currently available topical NSAIDs.
  • To compare the anesthetic properties of generic diclofenac, generic ketorolac, branded bromfenac, and branded nepafenac.

Main Methods:

  • Corneal sensitivity was measured in 10 healthy volunteers using a Cochet-Bonnet esthesiometer.
  • One drop of each NSAID was applied to the eye, with sensitivity measured post-application.
  • A washout period was implemented between testing different NSAIDs.

Main Results:

  • All tested NSAIDs showed a significant decrease in corneal sensitivity post-application.
  • The anesthetic effect peaked between 0-30 minutes and gradually returned to baseline by 60 minutes.
  • Diclofenac exhibited the greatest maximal decrease in corneal sensitivity, followed by ketorolac, bromfenac, and nepafenac.

Conclusions:

  • All four topical NSAIDs demonstrated comparable anesthetic effects.
  • The findings suggest similar anesthetic profiles for the evaluated topical NSAIDs.