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Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

Hua Deng1, Wei Wang1, Jianzhong Yu1

  • 1Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States.

Elife
|April 1, 2015
PubMed
Summary

Spectrin, a contractile protein, is identified as a new upstream regulator of the Hippo pathway. It modulates cytoskeletal tension and actomyosin activity, offering novel insights into how mechanical forces control tissue growth.

Keywords:
D. melanogastercell biologycell tensioncytoskeletondevelopmental biologymyosin activityorgan sizesignal transductionstem cells

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