Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.5K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.5K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.4K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.4K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

950
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
950
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

991
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
991

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trained immunity: Breaking a dogma and a missing opportunity in IBD?

Inflammatory bowel diseases·2026
Same author

Gastroenterologists' attitudes and challenges toward treat-to-target strategies in inflammatory bowel disease: a multinational survey.

Therapeutic advances in gastroenterology·2025
Same author

Towards IBD Prediction and Prevention: The Contribution of Genetics and Genomics.

Inflammatory bowel diseases·2025
Same author

Rewiring of Transcription Factor Binding: Another Piece of the Intricate Puzzle of IBD Pathogenesis.

Inflammatory bowel diseases·2025
Same author

The functional role of the extracellular matrix in inflammatory bowel disease associated gut fibrosis.

Matrix biology : journal of the International Society for Matrix Biology·2025
Same author

Cellular and molecular mechanisms in the pathogenesis of pouchitis: more than just the microbiota.

Gut·2025

Related Experiment Video

Updated: Apr 15, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.7K

Inflammatory bowel disease pathogenesis: where are we?

Claudio Fiocchi1

  • 1Department of Gastroenterology and Hepatology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA; Department of Pathobiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Journal of Gastroenterology and Hepatology
|April 2, 2015
PubMed
Summary

Understanding inflammatory bowel disease (IBD) requires integrating the exposome, genome, microbiome, and immunome. An "IBD integrome" approach using systems biology can advance IBD research and treatment.

Keywords:
Crohn's diseaseinflammatory bowel diseaseintegromepathogenesisulcerative colitis

More Related Videos

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

20.8K
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

4.7K

Related Experiment Videos

Last Updated: Apr 15, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.7K
Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

20.8K
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

4.7K

Area of Science:

  • Gastroenterology and Immunology
  • Systems Biology
  • Personalized Medicine

Background:

  • Inflammatory bowel disease (IBD) is a complex gastrointestinal disorder with significant research focus.
  • Advances in understanding IBD pathophysiology have led to successful novel therapies for gut inflammation.
  • Despite progress, a deeper understanding of IBD pathogenesis, early detection, lifestyle factors, and disease-modifying agents is needed.

Purpose of the Study:

  • To highlight the limitations in current IBD research due to the lack of integrated analysis of key pathogenic components.
  • To propose an "IBD integrome" approach for a comprehensive understanding of IBD.
  • To leverage systems biology for integrating diverse data to advance IBD research and treatment.

Main Methods:

  • Review and synthesis of current knowledge on IBD pathogenesis.
  • Conceptualization of the "IBD integrome" framework.
  • Application of systems biology principles for data integration.

Main Results:

  • Current IBD research often fails to integrate crucial elements like the exposome, genome, gut microbiome, and immunome.
  • An integrated "IBD integrome" approach is proposed as a novel strategy.
  • This approach aims to harness functional information from each component for a holistic view.

Conclusions:

  • A comprehensive understanding of IBD pathogenesis is hindered by fragmented research approaches.
  • The proposed "IBD integrome" approach, utilizing systems biology, offers a promising solution.
  • This integrated strategy is essential for advancing IBD research, enabling early detection, and developing effective treatments.