Related Experiment Video
Updated: Apr 15, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Small molecule glucagon receptor antagonists: a patent review (2011 - 2014)
1Cardiovascular, Metabolic and Endocrine Diseases Chemistry, Pfizer Worldwide Research and Development , 610 Main St, Cambridge, MA 02139 , USA +1 617 551 3267 ; kevin.filipski@pfizer.com.
Introduction:
Glucagon receptor antagonists (GCGRAs) have been an area of ongoing research in the pharmaceutical industry for more than two decades. Blocking the action of the glucagon peptide leads to repression of hepatic glucose production and reduced blood glucose. Small molecule GCGRAs continue to be pursued as a potential new treatment for diabetes.
Areas Covered:
The current review summarizes small molecule GCGRA patents and patent applications that first appeared during 2011 - 2014. The search term 'glucagon receptor' was used to find patents of the desired type.
Expert Opinion:
Several companies have brought forward GCGRAs into human clinical trials with the most advanced to date being in Phase II. This field is mature and the number of patents has been decreasing in the last few years.
Related Concept Videos
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Oral Hypoglycemic Agents: Glinides
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Hypoglycemia and Glucagon

