Related Experiment Video

Updated: Feb 16, 2026

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
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TREM2 enables amyloid β clearance by microglia.

Serge Rivest1

  • 1Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Blvd., Québec, Canada.

Cell Research
|April 2, 2015
PubMed
Summary

Deficiency in triggering receptor expressed on myeloid cells 2 (TREM2) worsens Alzheimer's disease pathology. This receptor is crucial for microglia's natural clearance of toxic amyloid beta protein.

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