Zein-based films and their usage for controlled delivery: Origin, classes and current landscape.

Area of Science:

• Biomaterials Science
• Pharmaceutical Technology
• Polymer Chemistry

Background:

• Zein, a maize protein, is a GRAS excipient approved by the US-FDA for pharmaceutical film coating.
• Its long-term use in tablets has not fully elucidated the effects of zein coating on tablet properties.
• Zein's potential extends to active ingredients in direct compressed tablets and film-based delivery systems.

Purpose of the Study:

• To review the current applications of zein as a thin film and uniform layer for biomedical uses.
• To summarize and analyze published studies on zein film properties and behaviors.
• To provide mechanistic insights into the relationship between zein films and improved pharmaceutical profiles.

Main Methods:

• Literature review of published works on zein films.
• Analysis of studies investigating zein film properties and behaviors.
• Synthesis of data to understand zein's role in drug delivery and biomedical applications.

Main Results:

• Zein films are investigated for diverse biomedical applications including medical devices, nanoparticles, quantum dots, and nanofibers.
• Studies reveal zein films can enhance various pharmaceutical properties.
• Mechanistic understanding of zein film behavior is crucial for optimizing its application.

Conclusions:

• Zein films offer significant potential as functional materials in drug delivery systems.
• Further research into zein film properties can unlock new biomedical applications.
• Zein's versatility supports its future use in advanced pharmaceutical and biomedical technologies.