Related Experiment Video
Updated: Apr 15, 2026

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
Published on: February 28, 2025
Diagnosis using nail matrix
Bertrand Richert1, Marie Caucanas1, Josette André1
1Dermatology Department, University Hospitals Brugmann, St Pierre and Queen Fabiola's Children Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Abstract:
Diagnosing nail matrix diseases requires knowledge of the nail matrix function and anatomy. This allows recognition of the clinical manifestations and assessment of potential surgical risk. Nail signs depend on the location within the matrix (proximal or distal) and the intensity, duration, and extent of the insult. Proximal matrix involvement includes nail surface irregularities (longitudinal lines, transverse lines, roughness of the nail surface, pitting, and superficial brittleness), whereas distal matrix insult induces longitudinal or transverse chromonychia. Clinical signs are described and their main causes are listed to enable readers to diagnose matrix disease from the nail's clinical features.
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