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The intraocular pressure and central corneal thickness in healthy premature infants
Damla Erginturk Acar1, Ugur Acar2, Zuhal Ozen Tunay1
1Department of Ophthalmology, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey.
Insights
Intraocular pressure (IOP) and central corneal thickness (CCT) are higher in premature infants with lower postconceptional age (PCA). These findings are crucial for understanding ocular development in preterm infants.
Area of Science:
- Ophthalmology
- Neonatology
- Pediatric Optometry
Background:
- Premature infants require careful monitoring for ocular health.
- Establishing normal ranges for intraocular pressure (IOP) and central corneal thickness (CCT) is essential for diagnosing potential conditions.
Purpose of the Study:
- To determine the normal values of intraocular pressure (IOP) and central corneal thickness (CCT) in healthy premature infants.
- To investigate the relationship between postconceptional age (PCA) and these ocular parameters.
Main Methods:
- Prospective enrollment of infants <32 weeks gestational age screened for retinopathy of prematurity.
- Standardized measurements of IOP via applanation tonometry and CCT using ultrasonic pachymetry.
- Statistical analysis including nonparametric tests and correlation to assess PCA's influence on IOP and CCT.
Main Results:
- A total of 470 infants were analyzed (mean PCA 35.94 ± 4.00 weeks).
- Mean IOP was 16.86 ± 2.93 mm Hg and mean CCT was 590 ± 58.26 μm.
- Significantly higher IOP and CCT were observed in infants with lower PCA, with a negative linear relationship noted.
Conclusions:
- Intraocular pressure and central corneal thickness values tend to be higher in premature infants with lower postconceptional ages.
- Elevated IOP in these infants may correlate with increased CCT, highlighting the importance of age-adjusted norms.
Purpose:
To describe the normal values of intraocular pressure (IOP) and central corneal thickness (CCT) in healthy premature infants.
Methods:
Infants of <32 weeks' gestational age who underwent screened for retinopathy of prematurity were prospectively enrolled. The same ophthalmologist measured IOP by applanation tonometry and CCT using ultrasonic pachymetry. Infants were divided into four groups according to postconceptional ages (PCA). The mean values of the IOP and CCT were compared by nonparametric statistical tests, and the relationship of the PCA with IOP and CCT were analyzed with correlation tests. Only right eye measurements were analyzed.
Results:
A total of 470 infants (mean PCA, 35.94 ± 4.00 weeks) were enrolled. The mean IOP with standard deviation was 16.86 ± 2.93 mm Hg; the mean CCT, 590 ± 58.26 μm. Both IOP and CCT values were found to be significantly higher in infants with lower versus higher PCA (P < 0.001). There was a statistically significant negative linear relationship between the PCA and the values of IOP and CCT, separately.
Conclusions:
IOP and CCT values may be higher in infants with lower PCA. Higher IOP values in these infants may be associated with higher CCT values.
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