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Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
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Published on: July 22, 2011

[Abnormality of T cell subsets in patients with idiopathic thrombocytopenic purpura]

L J Song, J R Yu, S J Ma

    Zhonghua Nei Ke Za Zhi
    |June 1, 1989
    PubMed

    Fifty patients with idiopathic thrombocytopenic purpura (ITP) and 50 normal controls were studied for T cell subsets using OKT monoclonal antibodies. These patients were found to have lower proportions of OKT4+ subset and higher proportions of OKT8+ ratio than the healthy controls. The perturbation was more severe in patients with active disease. A significant increase of OKT 4+8+ double-labelled cells deduced by a subtraction method was also observed in the peripheral blood of patients and an inverse correlation was demonstrated between the proportions of OKT4+8+ subset and the platelet counts. Furthermore, a positive correlation between the proportions of OKT4-8+ subset and the platelet counts was also found in patients with active ITP. These data suggest that abnormalities of T cell subsets in the peripheral blood may play an important role in the pathogenesis of ITP.

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