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Related Concept Videos

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

961
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
961
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. A Randomized Trial Of Laparoscopic Versus Open Surgery For Rectal Cancer.

A randomized trial of laparoscopic versus open surgery for rectal cancer.

H Jaap Bonjer1, Charlotte L Deijen, Gabor A Abis

  • 1From VU University Medical Center (H.J.B., C.L.D., G.A.A., M.A.C., M.H.G.M.P., E.S.M.L.-K.) and Amsterdam Medical Center (W.A.B.) - both in Amsterdam; Hospital Clinic I Provincial de Barcelona, Barcelona (A.M.L.); the Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital-Östra, Gothenburg, Sweden (J.A., E.A., E.H.); Herlev Hospital, Department of Surgery, University of Copenhagen, Copenhagen (J.R.); and Caritas Krankenhaus St. Josef, Regensburg, Germany (A.F.).

The New England Journal of Medicine
|April 2, 2015

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Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer

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Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
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Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
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View abstract on PubMed

Summary
This summary is machine-generated.

Laparoscopic surgery for rectal cancer shows similar locoregional recurrence and survival rates compared to open surgery. This study provides evidence for the efficacy of minimally invasive techniques in rectal cancer treatment.

Area of Science:

  • Surgical Oncology
  • Minimally Invasive Surgery
  • Gastrointestinal Surgery

Background:

  • Laparoscopic resection is common for colorectal cancer, but evidence comparing it to open surgery for rectal cancer outcomes is limited.
  • A clinical trial was designed to assess long-term oncological outcomes after laparoscopic versus open rectal cancer resection.

Purpose of the Study:

  • To compare 3-year locoregional recurrence rates after laparoscopic and open rectal cancer surgery.
  • To evaluate differences in disease-free and overall survival between the two surgical approaches.

Main Methods:

  • An international trial randomized 1044 patients with rectal adenocarcinoma to either laparoscopic or open surgery (2:1 ratio).
  • Patients had solitary tumors within 15 cm of the anal verge, without local invasion or distant metastases.

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  • Primary endpoint was locoregional recurrence at 3 years; secondary endpoints included disease-free and overall survival.

    • Main Results:

    • At 3 years, locoregional recurrence rates were 5.0% in both groups (0 percentage points difference).
    • Disease-free survival was 74.8% for laparoscopic and 70.8% for open surgery (4.0 percentage points difference).
    • Overall survival was 86.7% for laparoscopic and 83.6% for open surgery (3.1 percentage points difference).

    Conclusions:

    • Laparoscopic surgery for rectal cancer demonstrated comparable rates of locoregional recurrence to open surgery.
    • Disease-free and overall survival rates were also similar between laparoscopic and open surgical approaches for rectal cancer.