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The RAISE early treatment program for first-episode psychosis: background, rationale, and study design
John M Kane1, Nina R Schooler, Patricia Marcy
1Department of Psychiatry, The Zucker Hillside Hospital, 75-59 263rd St, Kaufmann Bldg, Ste 103, Glen Oaks, NY 11004 psychiatry@lij.edu.
The Journal of Clinical Psychiatry
|April 2, 2015
Summary
This study developed and tested a comprehensive treatment for early psychosis, aiming to improve patient quality of life and functional outcomes in real-world settings.
Area of Science:
- Psychiatry and Mental Health
- Clinical Trials and Health Services Research
- Schizophrenia Spectrum and Other Psychotic Disorders
Background:
- The National Institute of Mental Health Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP) addresses the need for improved outcomes in first-episode psychosis.
- Early intervention is critical for managing schizophrenia and related disorders, aiming to alter the long-term trajectory of the illness.
Purpose of the Study:
- To develop and evaluate a multimodal intervention combining pharmacologic and psychosocial treatments for first-episode psychosis (FEP).
- To assess the effectiveness of the experimental intervention compared to usual care on quality of life, remission, recovery, and cost-effectiveness in FEP patients.
- To implement and test this intervention in real-world, non-academic clinical settings.
Main Methods:
- A treatment model and training program were developed based on literature review and expert consultation.
- A cluster randomized controlled trial was conducted across 34 sites, assigning 17 to the experimental intervention and 17 to usual care.
- Eligible patients (15-40 years) with FEP received a minimum of 2 years of follow-up with blinded, centralized assessments via video.
Main Results:
- The study successfully developed a multimodal treatment intervention for real-world delivery.
- A controlled clinical trial was implemented to gather data on the intervention's effectiveness.
- Detailed results on the trial's outcomes (quality of life, remission, recovery, cost-effectiveness) will be published separately.
Conclusions:
- The RAISE-ETP successfully designed a multimodal treatment intervention suitable for real-world clinical settings.
- The study established a controlled clinical trial framework to evaluate the intervention's impact on early schizophrenia.
- This approach has the potential to significantly improve functional outcomes and quality of life for individuals experiencing their first episode of psychosis.
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