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Meta-analysis of microRNA-146a rs2910164 G>C polymorphism association with autoimmune diseases susceptibility, an
Changzheng Li1, Weijun Fu2, Yu Zhang3
1Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Background:
Published data showed that the susceptibility of autoimmune diseases (ADs) was associated with the polymorphism rs2910164 in microRNA-146a (miR-146a). However, the results remain controversial so far. Two meta-analyses published in 2013 and 2014 came to opposite conclusions. In order to derive a more precise estimation of the relationship, we performed this meta-analysis.
Methods:
We searched the PubMed, OvidSP and CNKI databases (published prior to September 8th, 2014) and extracted data from eligible studies. The procedure of meta-analysis was performed by using the Stata 12.0 software. Random effect model or fixed effect model were chosen respectively, according to the between study heterogeneities.
Results:
A total of 24 case-control studies, 11 more than previous meta-analysis on this topic, were involved. We took stratified analyses by different ethnicities and different types of diseases in different genetic models. In Caucasian subgroup, significant increased risks of GC genotype and GC+CC genotype with ADs susceptibility were found in heterozygote model (GC vs GG, OR = 1.38, 95% CI 1.04-1.83, p = 0.024) and dominant model (GC+CC vs GG, OR = 1.37, 95% CI 1.01-1.85, p = 0.041), respectively. Meanwhile, in other disease subgroup, significant increased risks of C allele, CC genotype and GC+CC genotype were found in allele model (C vs G, OR = 1.16, 95% CI 1.04-1.31, p = 0.010), homozygote model (CC vs GG, OR = 1.42, 95% CI 1.10-1.84, p = 0.006) and dominant model (GC+CC vs GG, OR = 1.25, 95% CI 1.04-1.51, p = 0.020), respectively.
Conclusions:
MiR-146a rs2910164 G>C polymorphism was associated with the susceptibility of ADs.
Insights
The microRNA-146a (miR-146a) rs2910164 G>C polymorphism is linked to autoimmune disease susceptibility. This meta-analysis clarifies the association, incorporating more studies than previous research.
Area of Science:
- Genetics
- Immunology
- Molecular Biology
Background:
- The microRNA-146a (miR-146a) rs2910164 polymorphism has been implicated in autoimmune disease (AD) susceptibility.
- Previous meta-analyses yielded conflicting results, necessitating further investigation.
- This study aims to provide a more precise estimation of the association between miR-146a rs2910164 and AD susceptibility.
Purpose of the Study:
- To conduct a comprehensive meta-analysis to clarify the association between the miR-146a rs2910164 polymorphism and autoimmune disease susceptibility.
- To resolve controversies arising from previous conflicting meta-analyses.
Main Methods:
- A systematic literature search was performed in PubMed, OvidSP, and CNKI databases up to September 8th, 2014.
- Data from 24 case-control studies were extracted and analyzed using Stata 12.0.
- Random or fixed effect models were employed based on heterogeneity assessment.
Main Results:
- The meta-analysis included 24 case-control studies, exceeding previous efforts.
- In Caucasians, the GC genotype and GC+CC genotype showed increased AD susceptibility in heterozygote and dominant models, respectively.
- In other disease subgroups, the C allele, CC genotype, and GC+CC genotype were associated with increased risks in allele, homozygote, and dominant models.
Conclusions:
- The miR-146a rs2910164 G>C polymorphism is significantly associated with autoimmune disease susceptibility.
- Stratified analyses by ethnicity and disease type provide further insights into this genetic association.
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