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Related Experiment Video

Updated: Apr 15, 2026

Humanized NOD/SCID/IL2r&#947;null (hu-NSG) Mouse Model for HIV Replication and Latency Studies
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Micronutrients in HIV: a Bayesian meta-analysis.

George M Carter1, Debbie Indyk2, Matthew Johnson3

  • 1Foundation for Integrative AIDS Research, Brooklyn, NY, United States of America.

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|April 2, 2015
PubMed
Summary
This summary is machine-generated.

Micronutrient supplementation (MNS) significantly slows disease progression in adults with HIV not on antiretroviral therapy. MNS may also reduce mortality, offering a low-cost intervention for HIV care.

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Area of Science:

  • Nutritional science
  • Infectious disease epidemiology
  • Public health interventions

Background:

  • Millions with HIV lack access to antiretroviral therapy (ART).
  • Micronutrient deficiencies are prevalent in HIV disease.
  • Micronutrient supplementation (MNS) may impact HIV progression and mortality.

Purpose of the Study:

  • To synthesize evidence on MNS effects on disease progression and mortality in HIV.
  • To evaluate MNS as a potential intervention for HIV management.

Main Methods:

  • Systematic review of multiple databases (MEDLINE, EMBASE, Cochrane, AMED, CINAHL) through December 2014.
  • Inclusion of studies with >3 micronutrients versus control.
  • Hierarchical Bayesian random-effects modeling for data synthesis.

Main Results:

  • MNS significantly slowed disease progression in HIV+ adults not on ART (RR 0.62; 95% CrI: 0.37, 0.96).
  • The number needed to treat (NNT) to prevent disease progression was 8.4.
  • MNS showed a possible reduction in mortality (RR 0.84; 95% CrI: 0.38, 1.85), with an NNT of 25.

Conclusions:

  • MNS substantially slows disease progression in HIV+ adults not on ART.
  • MNS possibly reduces mortality and is highly effective (97.9% probability).
  • Given low cost and safety, MNS should be considered standard care for this population.