A physical map linking the five CD1 human thymocyte differentiation antigen genes.

¹Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.

|December 1, 1989

Summary

Researchers mapped the five human CD1 genes on chromosome 1. They determined the precise order and spacing of these genes within the CD1 complex using advanced molecular techniques.

Related Concept Videos

You might also read

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026

Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026

Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026

Area of Science:

Immunogenetics
Molecular Biology

Background:

Human CD1 molecules are cell surface glycoproteins involved in immune responses.
They are structurally related to MHC class I and II molecules but encoded by independent genes.
Five human CD1 genes (CD1A, -B, -C, -D, -E) have been identified, with functions of CD1D and CD1E products yet to be fully elucidated.

Purpose of the Study:

To physically map and characterize the organization of the human CD1 gene cluster.
To determine the order and inter-gene distances within the CD1 locus on chromosome 1.

Main Methods:

Pulse field gel electrophoresis
Cosmid cloning
DNA walking techniques

Main Results:

Established tight linkage of all five human CD1 genes.
Spanned 190 kb of DNA containing the entire CD1 gene complex using 14 overlapping cosmids.
Determined the gene order as CD1D-CD1A-CD1C-CD1B-CD1E.
Found that most CD1 genes share the same transcriptional orientation, with a larger intergenic distance between CD1D and CD1A.

Conclusions:

The human CD1 gene family is tightly clustered on chromosome 1.
Detailed physical mapping provides a framework for further functional studies of CD1 genes and their products.

Related Experiment Videos

A physical map linking the five CD1 human thymocyte differentiation antigen genes.

Related Concept Videos

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Related Experiment Videos

A physical map linking the five CD1 human thymocyte differentiation antigen genes.

Related Concept Videos

Related Articles

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions: