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Related Concept Videos

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Related Experiment Video

Updated: Apr 15, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Lymphocyte 'homing' and chronic inflammation.

Yasuhiro Sakai1, Motohiro Kobayashi1

  • 1Division of Tumor Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.

Pathology International
|April 3, 2015
PubMed
Summary

Chronic inflammation drives lymphoid neogenesis, forming tertiary lymphoid tissues. HEV-like vessels in inflamed tissues mimic normal lymphoid organs, recruiting lymphocytes via similar adhesion mechanisms.

Keywords:
Helicobacter pylori gastritisMALT lymphomaautoimmune pancreatitischronic inflammationhigh endothelial venule (HEV)inflammatory bowel disease (IBD)lymphocyte homingmucosal addressin cell adhesion molecule 1 (MAdCAM-1)peripheral lymph node addressin (PNAd)tertiary lymphoid tissue

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Area of Science:

  • Immunology
  • Pathology
  • Cell Biology

Background:

  • Chronic inflammation involves prolonged tissue injury and lymphocyte accumulation.
  • Inflamed tissues can develop lymphoid neogenesis, forming tertiary lymphoid tissues.
  • Lymphocyte recruitment in inflammation resembles physiological homing to lymphoid organs.

Purpose of the Study:

  • To review physiological lymphocyte homing mechanisms.
  • To describe the role of high endothelial venule (HEV)-like vessels in chronic inflammation.
  • To discuss HEV-like vessel-mediated pathogenesis in various chronic inflammatory disorders.

Main Methods:

  • Review of physiological lymphocyte homing.
  • Analysis of HEV-like vessel formation in chronic inflammation.
  • Examination of pathogenesis in specific inflammatory conditions.

Main Results:

  • Physiological lymphocyte homing involves interactions between homing receptors and vascular addressins on HEVs.
  • HEV-like vessels are induced de novo in chronic inflammatory sites.
  • These HEV-like vessels facilitate lymphocyte recruitment, contributing to pathogenesis.

Conclusions:

  • Lymphocyte recruitment in chronic inflammation utilizes mechanisms similar to physiological homing.
  • HEV-like vessels play a significant role in the pathogenesis of chronic inflammatory disorders.
  • Understanding these mechanisms is crucial for managing inflammatory diseases.