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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
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Pregnancy outcome in patients with systemic vasculitis: a single-centre matched case-control study
Shirish R Sangle1, Periklis Vounotrypidis1, Annette Briley2
1The Lupus Research Unit, The Rayne Institute, St Thomas' Hospital.
Rheumatology (Oxford, England)
|April 3, 2015
Summary
Pregnancy in women with systemic vasculitis (SV) results in earlier deliveries but similar birth weights compared to healthy controls. Women with SV face increased risks of pregnancy complications and disease flares during and after pregnancy.
Area of Science:
- Rheumatology
- Obstetrics
- Immunology
Background:
- Systemic vasculitis (SV) encompasses a group of autoimmune diseases characterized by inflammation of blood vessels.
- Pregnancy outcomes in SV patients are not well-established, necessitating further research into potential maternal and fetal complications.
Purpose of the Study:
- To compare pregnancy outcomes in patients with systemic vasculitis (SV) against age-, BMI-, and ethnicity-matched healthy pregnant controls.
- To identify specific risks and complications associated with pregnancy in women diagnosed with SV.
Main Methods:
- A retrospective study of 51 pregnancies in 29 SV patients, including various types of vasculitis like granulomatosis with polyangiitis (GPA) and Takayasu's arteritis.
- Inclusion of BVAS and vasculitis damage index evaluation.
- Comparison with 62 healthy women and 156 pregnancies, matched for age, BMI, and ethnicity.
Main Results:
- Median gestational age at delivery was significantly lower in the SV group (36.2 weeks) compared to controls (40 weeks).
- Median birth weight was lower in the SV group (3.0 kg) versus controls (3.5 kg), though customized birth weight percentiles were similar.
- SV patients experienced higher rates of miscarriage (13/9), pre-eclampsia (3/1), and intrauterine death (2/1); 8 patients flared during pregnancy and 11 postpartum.
Conclusions:
- Systemic vasculitis is associated with reduced gestational age at delivery but comparable customized birth weights in infants.
- Women with SV have an elevated risk of pregnancy morbidity, including miscarriage and pre-eclampsia.
- Disease flares are common in SV patients during pregnancy and the postpartum period, highlighting the need for close monitoring.
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