Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transmission Electron Microscopy01:15

Transmission Electron Microscopy

8.0K
In 1931, physicist Ernst Ruska—building on the idea that magnetic fields can direct an electron beam just as lenses can direct a beam of light in an optical microscope—developed the first prototype of the electron microscope. This development led to the development of the field of electron microscopy. In the transmission electron microscope (TEM), electrons are produced by a hot tungsten element and accelerated by a potential difference in an electron gun, which gives them up to 400...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polarizer-assisted pupillometry through closed eyelids, overcoming pupil position dependence.

Journal of biomedical optics·2026
Same author

Label-Free Metabolic Imaging In Vivo by Two-Photon Fluorescence Lifetime Endomicroscopy.

ACS photonics·2024
Same author

Healthcare delivery in the arctic-telehealth prospects.

International journal of circumpolar health·2024
Same author

Touchless short-wave infrared imaging for dynamic rapid pupillometry and gaze estimation in closed eyes.

Communications medicine·2024
Same author

2nd Spring Biophotonics Conference in Porto.

Journal of biophotonics·2024
Same author

The low-LET radiation contribution to the tumor dose in diffusing alpha-emitters radiation therapy.

Medical physics·2023

Related Experiment Video

Updated: Apr 15, 2026

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments
06:40

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments

Published on: January 28, 2021

4.8K

Proposed method for internal electron therapy based on high-intensity laser acceleration.

Michal Tepper1, Uri Barkai2, Israel Gannot3

  • 1Tel Aviv University, Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv 6997801, Israel.

Journal of Biomedical Optics
|April 3, 2015
PubMed
Summary

This study introduces a novel internal electron therapy using laser-accelerated electrons to precisely target tumors. This innovative radiotherapy approach minimizes damage to healthy tissues, offering a safer cancer treatment option.

More Related Videos

Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments
08:31

Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments

Published on: June 27, 2022

2.5K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.3K

Related Experiment Videos

Last Updated: Apr 15, 2026

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments
06:40

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments

Published on: January 28, 2021

4.8K
Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments
08:31

Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments

Published on: June 27, 2022

2.5K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.3K

Area of Science:

  • Medical Physics
  • Oncology
  • Laser Technology

Background:

  • Radiotherapy using high-energy photons can damage healthy tissues due to limited precision.
  • Current cancer treatments face challenges in discriminating between malignant and healthy cells.
  • Undesired side effects are a significant concern in conventional radiotherapy.

Purpose of the Study:

  • To propose and simulate a novel internal electron therapy method using laser-accelerated electrons.
  • To demonstrate the feasibility of creating patient-specific radiation profiles for cancer treatment.
  • To minimize damage to healthy tissues during radiotherapy.

Main Methods:

  • Development of a simulation model for laser-accelerated electrons within biological tissue.
  • Optimization of optical waveguides for high-intensity laser transmission.
  • Validation of simulation results against theoretical predictions for laser intensities up to 2 × 10(20) W/cm2.
  • Calculation of treatment profiles for two distinct tumor scenarios.

Main Results:

  • The simulation accurately models electron trajectories based on laser properties.
  • Validated simulation successfully calculated treatment profiles for targeted tumors.
  • Demonstrated the ability to design radiation profiles that cover tumor areas effectively.
  • Showcased minimal damage to adjacent healthy tissues in simulated treatment plans.

Conclusions:

  • Laser-accelerated internal electron therapy presents a promising alternative to conventional radiotherapy.
  • This method allows for precise, patient-specific tumor targeting.
  • The proposed technique has the potential to significantly reduce radiotherapy side effects.