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Use of gemcitabine-platinum in Indian patients with advanced gall bladder cancer
Bhawna Sirohi1, Sameer Rastogi, Ashish Singh
1Department of Medical Oncology, Tata Memorial Centre, Parel, Mumbai, India.
Background:
Gemcitabine-platinum (Gem-P) is the current standard for patients with advanced gall bladder cancer.
Materials & Methods:
This is retrospective analysis of a prospectively maintained database of 210 patients with advanced gall bladder cancer treated with Gem-P between January 2012 and September 2013.
Results:
Median age was 53 years, 65.2% females. In total,158 patients had metastatic and 52 had locoregional disease. Median number of cycles was 5 (1-12). At a median follow-up of 10 months, median overall survival/progression-free survival was 10/5 months, respectively. On multivariate analysis, patients who underwent prior surgery for primary and locoregional disease had a significantly better progression-free survival and those with locoregional disease had a significantly better overall survival. A total of 45.7% received second-line chemotherapy.
Conclusion:
Use of Gem-P in Indian patients leads to slightly worse outcomes suggesting an aggressive biology.
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