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Temozolomide-based combination for advanced neuroendocrine neoplasms: a systematic review of the literature

Omar Abdel-Rahman1, Mona Fouad

  • 1Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Future Oncology (London, England)
|April 3, 2015
PubMed
Abstract

Insights

Temozolomide (TMZ)-based combinations show promise for advanced neuroendocrine neoplasms (NENs). Combining TMZ with agents like capecitabine may offer an effective treatment option for these challenging cancers.

Area of Science:

  • Oncology
  • Clinical Pharmacology

Background:

  • Neuroendocrine neoplasms (NENs) represent a diverse group of tumors.
  • Advanced NENs often require systemic therapy for disease control.

Purpose of the Study:

  • To systematically review the efficacy and safety of temozolomide (TMZ)-based combination therapies for advanced NENs.
  • To evaluate progression-free survival, overall survival, toxicities, and tumor response.

Main Methods:

  • Systematic literature search using terms 'NENs,' 'TMZ,' and 'systemic therapy.'
  • Inclusion of 16 trials involving 348 patients.

Main Results:

  • Median progression-free survival varied from 6 to 31 months.
  • Disease control rates ranged from 65% to 100%.
  • Common grade 3/4 toxicities included leukopenia, lymphopenia, and elevated transaminases.

Conclusions:

  • Temozolomide (TMZ)-based combinations, particularly with capecitabine, appear effective for advanced low-intermediate grade NENs.
  • Further research may refine optimal combination strategies and patient selection.
Keywords:
combination regimensneuroendocrine neoplasmssystemic therapytemozolomide

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