Speech production, intelligibility and oromotor function in seven individuals with Möbius sequence

Area of Science:

• Neurology
• Speech-Language Pathology

Background:

• Möbius sequence is a rare congenital disorder affecting cranial nerves, primarily causing facial and abducent nerve palsy.
• Associated conditions include cleft palate, intellectual disability, and neuropsychiatric disorders.

Purpose of the Study:

• To investigate speech production, intelligibility, and oromotor function in individuals with Möbius sequence.
• To provide deeper insights into the functional impact of this rare neurological condition.

Main Methods:

• A case series involving seven participants (three children, four adults) with Möbius sequence.
• Evaluations included perceptual assessments of speech intelligibility and orofacial function, alongside objective measurements of nasality, lip, and tongue force.

Main Results:

• Speech intelligibility ranged from severely impaired to fully intelligible among participants.
• Percentage of phonemes correct (PPC) varied widely (59.3-100%).
• Facial palsy and tongue impairment were common, with some individuals utilizing compensatory strategies effectively.

Conclusions:

• This study enhances understanding of speech and oromotor capabilities in Möbius sequence.
• Findings highlight the variability in functional outcomes and the role of compensatory mechanisms.