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Updated: Apr 15, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Continuing to challenge practice to be evidence based.
Mary Beth Flynn Makic1, Carol Rauen2, Kimmith Jones2
1Mary Beth Flynn Makic is a research nurse scientist in critical care at University of Colorado Hospital and an associate professor at the University of Colorado, College of Nursing, Aurora, Colorado.Carol Rauen is an independent clinical nurse specialist and education consultant in The Outer Banks of North Carolina.Kimmith Jones is the director of translation to nursing practice at the University of Maryland Medical Center, Baltimore, Maryland.Anna C. Fisk is a senior leadership nurse in the cardiac intensive care unit at Boston Children's Hospital, Boston, Massachusetts. marybeth.makic@uchealth.org.
Critical care nurses should update practice habits by adopting evidence-based interventions. Reviewing weight-based medication, chest tube care, sedation, and chest physiotherapy reveals outdated practices that may be harmful.
Area of Science:
- Critical care nursing
- Evidence-based practice
Background:
- Clinical practice often relies on established habits rather than current evidence.
- Critical care nurses are encouraged to re-evaluate interventions based on research findings.
Purpose of the Study:
- To challenge critical care nurses to examine evidence guiding nursing practice interventions.
- To review four common critical care interventions and compare them with current evidence.
Main Methods:
- Review of literature and evidence for four common critical care interventions.
- Analysis of current recommendations for weight-based medication administration, chest tube patency, sedation interruption, and chest physiotherapy.
Main Results:
- Actual patient weight is crucial for accurate medication dosing; estimates are insufficient, especially in obese patients.
- Chest tube stripping and milking are not necessary for maintaining patency and may cause harm.
- Daily interruption of sedation is appropriate for most mechanically ventilated patients.
- Chest physiotherapy is ineffective for pediatric respiratory conditions and post-extubation atelectasis.
Conclusions:
- Critical care nurses must critically evaluate their practices against current evidence.
- Adopting evidence-based interventions is essential for improving patient outcomes and safety in critical care settings.
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