Rabies viral vectors for monosynaptic tracing and targeted transgene expression in neurons

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Ian R Wickersham1, Heather A Sullivan2

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Cold Spring Harbor Protocols
|April 3, 2015
PubMed

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Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...