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A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
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A case of spitzoid melanoma
Heung Yeol Kim1, Jong Hyun Yoon1, Eun Byul Cho1
1Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Annals of Dermatology
|April 3, 2015
Summary
Spitzoid melanoma, a rare skin cancer subtype, often mimics benign Spitz nevi, making diagnosis challenging. Early detection relies on identifying key features like asymmetry and size, crucial for distinguishing it from benign lesions.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Spitzoid melanoma is a melanoma subtype that clinically and histologically resembles a Spitz nevus.
- Distinguishing between Spitz nevus and spitzoid melanoma is challenging due to varied clinical presentations and lack of pigmentation.
Observation:
- Spitzoid melanomas often present as amelanotic nodular lesions, typically exceeding 1 cm in diameter.
- Clinical diagnosis is frequently missed due to diverse appearances and amelanosis.
- Giant cells, rarely reported in melanoma, can lead to misdiagnosis as histiocytic tumors.
Findings:
- Asymmetrical shape, diameter >1 cm, deep invasive component, and high cytologic atypia favor spitzoid melanoma diagnosis.
- The presence of giant cells in melanoma is rare and can cause diagnostic confusion.
Implications:
- Accurate differentiation between Spitz nevi and spitzoid melanoma is critical for appropriate patient management.
- Awareness of atypical features, including giant cells, is essential for pathologists and dermatologists to avoid misdiagnosis.
- This case highlights the diagnostic challenges posed by spitzoid melanoma, emphasizing the need for vigilance.
