Related Experiment Video For Colon cancer
Updated: Apr 15, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids
Duan Dongfeng1, Chen An1, Peng Shujia1
1Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
Background:
The colon plays a key role in regulating the homeostasis of bile acids.
Aim:
The present study aims to evaluate the influence of colon cancer towards the homeostasis of bile acids.
Methods:
The free and conjugated bile acids were determined using ultraperformance LC (UPLC) coupled with ABI 4000 QTRAP triple quadrupole instruments.
Results:
The results showed that the free bile acids in serum of patients with colon cancers tend to increase, and the conjugated bile acids tended to decrease, especially for taurolithocholate (TLCA) (p<0.001).
Conclusion:
The alteration of bile acids balance in colon cancers indicated the possibility of complicated diseases due to the disrupted balance of bile acids.
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