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The MS4A family: counting past 1, 2 and 3

Li Eon Kuek1, Melanie Leffler2, Graham A Mackay1

  • 1Department of Pharmacology and Therapeutics, and Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia.

Immunology and Cell Biology
|April 4, 2015
PubMed

Insights

The membrane-spanning 4-domain family, subfamily A (MS4A) proteins, including CD20, regulate leukocyte function. This review explores the broader MS4A family

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • The MS4A family includes well-characterized proteins like MS4A1 (CD20) involved in leukocyte activation.
  • Many MS4A family members have roles in cell activation, growth, and development.
  • Understanding of numerous MS4A family members beyond MS4A1-3 is limited.

Purpose of the Study:

  • To review the structure, expression, regulation, and biological roles of the larger MS4A protein family.
  • To highlight emerging roles of MS4A proteins in cellular processes.
  • To present research on MS4A8B and its potential function in epithelial cells.

Main Methods:

  • Literature review of MS4A family members.
  • Analysis of protein structure, expression patterns, and regulation.
  • Discussion of characterized and emerging biological functions.
  • Inclusion of specific research findings on MS4A8B.

Main Results:

  • MS4A proteins are cell surface molecules with diverse functions.
  • MS4A1-3 are key regulators of leukocyte subsets.
  • Emerging evidence suggests broader roles for other MS4A members, including MS4A8B in epithelial cells.

Conclusions:

  • The MS4A family is diverse, with significant roles beyond well-known members.
  • Further research is needed to fully elucidate the functions of many MS4A proteins.
  • MS4A8B shows potential involvement in epithelial cell regulation.

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