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Updated: Apr 15, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Vascularization strategies for tissue engineers.

Lindsey Dew¹, Sheila MacNeil, Chuh Khiun Chong

¹Department of Materials Science & Engineering, Kroto Research Institute, North Campus, University of Sheffield, Broad Lane, Sheffield S3 7HQ, UK.

Regenerative Medicine

|April 4, 2015

Summary

This summary is machine-generated.

Tissue-engineered substitutes need vascular networks for survival. This review explores strategies to accelerate vascular ingrowth, preventing tissue death from nutrient starvation.

Keywords:

angiogenesis blood vessels clinical application neovascularization regenerative medicine tissue engineering

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Last Updated: Apr 15, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

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Published on: August 11, 2017

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

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Published on: May 30, 2016

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Vascular Biology

Background:

Tissue-engineered substitutes require vascularization for in vivo survival.
Natural vascular ingrowth into engineered tissues is slow, leading to nutrient deprivation and cell death.
Cornea and cartilage are exceptions, not requiring extensive vascular networks.

Purpose of the Study:

To review the processes and factors involved in new blood vessel formation (neovascularization).
To summarize current and emerging strategies for accelerating neovascularization in tissue engineering.
To discuss future directions for overcoming vascularization challenges.

Main Methods:

Literature review of neovascularization processes.
Summary of various approaches to enhance vascularization in tissue-engineered constructs.
Discussion of potential future strategies.

Main Results:

Neovascularization is crucial for engineered tissue survival.
Slow vascular ingrowth is a major limitation in tissue engineering.
Multiple strategies are being developed to address this limitation.

Conclusions:

Accelerating vascularization is key to successful tissue engineering.
Current and future strategies aim to improve nutrient and oxygen supply to engineered tissues.
Overcoming slow neovascularization will enhance the clinical applicability of tissue-engineered substitutes.