Computational cardiac electrophysiology: implementing mathematical models of cardiomyocytes to simulate action potentials of the heart
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Updated: Apr 15, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Michael M Bell1, Elizabeth M Cherry
1School of Mathematical Sciences, Rochester Institute of Technology, Rochester, NY, USA.
Abstract:
Mathematical models are now an important tool for studying cardiac electrophysiology and arrhythmias. Utilizing these models to quantify behavior and make predictions requires solving the models computationally using numerical schemes. We discuss different solution methods and other computational considerations for simulating cardiac action potentials in single cells and multicellular preparations.
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