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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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Pulmonary Embolism I: Introduction01:29

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Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
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Other Pulmonary Disorders01:17

Other Pulmonary Disorders

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

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Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Related Experiment Video

Updated: Apr 15, 2026

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
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Pulmonary vasculitis.

Lindsay Lally1, Robert F Spiera1

  • 1Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.

Rheumatic Diseases Clinics of North America
|April 4, 2015
PubMed
Summary
This summary is machine-generated.

Pulmonary vasculitis involves inflammation of lung blood vessels, most commonly small capillaries. Antineutrophil cytoplasmic antibody-associated vasculitides are frequently observed and are the main focus of this review.

Keywords:
ANCA-associated vasculitisAntiglomerular basement membrane diseaseAntiphospholipid syndromeBehçet syndromeDiffuse alveolar hemorrhageGranulomatosis with polyangiitis (Wegener)Microscopic polyangiitisTakayasu arteritis

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Angiogenesis in the Ischemic Rat Lung
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Area of Science:

  • Pulmonary medicine
  • Rheumatology
  • Pathology

Background:

  • Pulmonary vasculitis is inflammation of the lung's blood vessels, affecting various sizes from capillaries to large arteries.
  • Small pulmonary capillaries are most frequently involved.
  • Antineutrophil cytoplasmic antibody-associated vasculitides (AAV) are a primary cause of small vessel pulmonary vasculitis.

Purpose of the Study:

  • To review the key aspects of pulmonary vasculitis, with a focus on AAV.
  • To discuss the spectrum of vasculitic involvement in pulmonary vessels, including large vessel types.

Main Methods:

  • Literature review focusing on antineutrophil cytoplasmic antibody-associated vasculitides.
  • Discussion of large vessel vasculitides affecting the pulmonary vasculature.

Main Results:

  • Small vessel vasculitis, particularly AAV (granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis), is the most common form of pulmonary vasculitis.
  • Large vessel pulmonary vasculitis, seen in Behçet syndrome and Takayasu arteritis, is also considered.

Conclusions:

  • Pulmonary vasculitis is a significant condition primarily involving small vessels, often linked to AAV.
  • Understanding the different types of pulmonary vasculitis is crucial for diagnosis and management.