Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fetal Circulation

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

Development of the Oral Microbiota

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

Functions of Life

Functions of Life

Human life is characterized by a variety of functions that are essential for survival and well-being. These functions include metabolism, movement, development, growth and reproduction.
Metabolism
The basic function of an organism is to consume energy and molecules in foods, convert some of it into fuel for movement, sustain body functions, and build and maintain body structures. There are two types of reactions that accomplish this: anabolism and catabolism.
Anabolism is the process whereby...

Development of Blood Vessels

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reducing Golden Hour Admission Times for Extremely Preterm Infants: An Improvement Science Initiative.

American journal of perinatology·2025

Same author

Acute Kidney Injury and Neurodevelopmental Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.

JAMA network open·2025

Same author

Multicenter Evaluation of a New Strip-Based Blood Glucose System for Point-of-Care Testing in Critical and Non-Critical Care Settings.

Journal of diabetes science and technology·2025

Same author

Correction: Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm.

Pediatric research·2024

Same author

Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm.

Pediatric research·2024

Same author

A Deep Intronic PKHD1 Variant Identified by SpliceAI in a Deceased Neonate With Autosomal Recessive Polycystic Kidney Disease.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2024

Search research articles

Related Experiment Video

Updated: Apr 15, 2026

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids

Published on: November 15, 2019

Transition from fetus to newborn.

Jonathan R Swanson¹, Robert A Sinkin¹

¹Division of Neonatology, Department of Pediatrics, University of Virginia Children's Hospital, Box 800386, Charlottesville, VA 22908, USA.

Pediatric Clinics of North America

|April 4, 2015

Summary

This summary is machine-generated.

The transition from fetus to newborn requires monitoring, as 10% of infants need support. Neonatal Resuscitation Program personnel ensure timely care for newborns experiencing a difficult cardiopulmonary transition at birth.

Keywords:

Fetal circulation Neonatal resuscitation program Neonate Physiology Resuscitation Transition

More Related Videos

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

A Swine Model of Neonatal Asphyxia

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Related Experiment Videos

Last Updated: Apr 15, 2026

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids

Published on: November 15, 2019

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

A Swine Model of Neonatal Asphyxia

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Area of Science:

Neonatology
Perinatal Physiology

Background:

The transition from fetal to neonatal life is a critical period.
Cardiopulmonary adaptation at birth is essential for newborn survival.
Approximately 10% of newborns require assistance during this transition.

Purpose of the Study:

To highlight the importance of monitoring the fetus to newborn transition.
To emphasize the need for clinician awareness of neonatal cardiopulmonary adaptation.
To underscore the necessity of trained personnel for neonatal resuscitation.

Main Methods:

Observational review of physiological processes during birth.
Analysis of outcomes for newborns requiring transitional support.
Assessment of the role of Neonatal Resuscitation Program (NRP).

Main Results:

Newborn transition is a complex physiological process.
Specific interventions are required for approximately 10% of neonates.
Prompt and appropriate care is crucial for optimal outcomes.

Conclusions:

Close monitoring of the newborn transition is vital.
Clinicians must understand cardiopulmonary adaptation at birth.
Availability of trained Neonatal Resuscitation Program personnel improves neonatal outcomes.