Related Experiment Video

Updated: Apr 15, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

7.1K

A practical guide to the diagnosis, treatment, and prevention of neonatal infections

Roberto Parulan Santos1, Debra Tristram2

  • 1Pediatric Infectious Diseases, Bernard & Millie Duker Children's Hospital, Albany Medical Center, 47 New Scotland Avenue (MC88), Albany, NY 12208, USA.

Pediatric Clinics of North America
|April 4, 2015
PubMed

Insights

Neonatal infections cause significant infant illness and death. This article offers practical, evidence-based strategies for diagnosing, managing, and preventing early-onset sepsis in newborns.

Area of Science:

  • Neonatal Medicine
  • Pediatric Infectious Diseases
  • Immunology

Background:

  • Neonatal infections are a major cause of infant morbidity and mortality.
  • Early-onset sepsis affects approximately 0.98 per 1000 live births within 3 days of life.
  • Newborns possess a relative immunodeficiency, increasing infection susceptibility.

Purpose of the Study:

  • To provide evidence-based practical approaches for neonatal infections.
  • To outline diagnostic criteria and management protocols.
  • To detail prevention strategies for neonatal infections.

Main Methods:

  • Review of current literature and clinical guidelines.
  • Synthesis of evidence for diagnosis, treatment, and prevention.
  • Focus on practical application in clinical settings.

Main Results:

  • Established incidence rates for early-onset sepsis.
  • Highlighted the increased risk due to neonatal immunodeficiency.
  • Presented a comprehensive framework for neonatal infection care.

Conclusions:

  • Effective diagnosis, management, and prevention are crucial for reducing neonatal infection impact.
  • Evidence-based strategies can improve outcomes for infected newborns.
  • Addressing neonatal immunodeficiency is key to infection control.

Keywords:
Antibacterial therapyAntiviral therapyEarly-onset sepsisLate-onset sepsisNeonatal antimicrobial stewardshipNeonatal infectionsNewborn sepsisRespiratory viral infections in infants

More Related Videos

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure05:50

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

Published on: March 12, 2020

15.1K
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

53.0K

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
5.0K
Nursing Interventions II: Selecting and Classifying the Nursing Interventions01:29

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
3.7K
Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
5.1K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
4.1K
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
44
Standard Precaution01:26

Standard Precaution

Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
3.5K