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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Anilide formation from thioacids and perfluoroaryl azides.

Sheng Xie1, Ryo Fukumoto1, Olof Ramström1

  • 1†Department of Chemistry, KTH-Royal Institute of Technology, Teknikringen 36, S-10044 Stockholm, Sweden.

The Journal of Organic Chemistry
|April 4, 2015
PubMed
Summary

A novel metal-free reaction efficiently forms anilides from perfluoroaryl azide and thioacid. This fast, high-yield method is chemoselective and functional-group tolerant, even in aqueous systems.

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