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Related Experiment Video

Updated: Apr 15, 2026

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Smoldering multiple myeloma.

S Vincent Rajkumar1, Ola Landgren2, María-Victoria Mateos3

  • 1Division of Hematology, Mayo Clinic, Rochester, MN;

Blood
|April 4, 2015
PubMed
Summary
This summary is machine-generated.

Smoldering multiple myeloma (SMM) is a precursor to multiple myeloma (MM). Recent advances refine SMM diagnosis and risk stratification, enabling earlier intervention for high-risk patients.

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Area of Science:

  • Hematology
  • Oncology
  • Clinical Medicine

Background:

  • Smoldering multiple myeloma (SMM) is a clonal plasma cell disorder with a higher progression risk than monoclonal gammopathy of undetermined significance.
  • Recent years have seen significant advancements in SMM diagnosis, prognosis, and management.
  • A subset of SMM patients are now reclassified as multiple myeloma (MM) based on biomarkers indicating a high risk of progression.

Purpose of the Study:

  • To review current concepts in the diagnosis and risk stratification of SMM.
  • To provide recommendations for the management of SMM.
  • To highlight the importance of early therapy for SMM patients.

Main Methods:

  • Review of recent literature on SMM diagnosis, prognosis, and management.
  • Incorporation of revised disease definitions and new prognostic factors.
  • Classification based on cytogenetic changes and biomarker identification.

Main Results:

  • Revised disease definition for SMM.
  • Identification of new prognostic factors and cytogenetic classifications.
  • Biomarker-based reclassification of high-risk SMM to MM.

Conclusions:

  • Accurate diagnosis and risk stratification of SMM are crucial.
  • Early therapy may benefit high-risk SMM patients.
  • Routine incorporation of modern imaging and laboratory techniques is recommended for SMM management.