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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Drug Delivery Systems: Different Types01:27

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Updated: Apr 15, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Non-Spherical Particles for Targeted Drug Delivery.

Jinrong Chen1, Nicholas Clay1, Hyunjoon Kong2

  • 1Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana IL, 61801, USA.

Chemical Engineering Science
|April 4, 2015
PubMed
Summary

Non-spherical nanoparticles offer improved drug loading and targeted delivery compared to spherical ones. This review explores their preparation and impact on biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Nano- and microparticles are crucial for delivering bioimaging agents and therapeutics.
  • Current spherical particles face limitations in drug loading and targeting efficiency.
  • Emerging research highlights the significant role of particle shape in targeted delivery.

Purpose of the Study:

  • To review methods for preparing non-spherical nano- and micro-particles.
  • To summarize research on how particle shape influences cargo loading, delivery, and release.
  • To identify future directions for optimizing non-spherical particle properties.

Main Methods:

  • Literature review of simulation and in vitro experimental studies.
  • Analysis of particle preparation techniques for non-spherical morphologies.
  • Synthesis of findings on shape-dependent cargo encapsulation and release kinetics.

Main Results:

  • Particle shape significantly impacts the efficiency of loading and targeted delivery of bioactive cargos.
  • Non-spherical particles demonstrate potential for enhanced circulation time and tissue targeting.
  • Various methods exist for fabricating non-spherical nano- and micro-particles.

Conclusions:

  • Non-spherical particle design is a promising strategy to overcome limitations of spherical carriers.
  • Further research into shape optimization can significantly advance targeted drug delivery and bioimaging.
  • Continued exploration of fabrication methods and shape-effect studies is essential for biomedical applications.