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Variations of sotalol kinetics in renal insufficiency
M Dumas1, P d'Athis, J F Besancenot
1Départment de Pharmacologie Clinique, Hopital Général, CHRU, Dijon, France.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|October 1, 1989
Abstract:
Decreased elimination of sotalol (160 mg) is found in patients with renal insufficiency. Simulation of plasma concentrations at steady-state exhibits moderately higher concentrations when creatinine clearance is between 10 and 30 ml/min and very high plasma concentrations when creatinine clearance is less than 10 ml/min suggesting, if treatment is absolutely necessary, monitoring in these cases and the reduction of the dose in major renal insufficiency.