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Updated: Apr 15, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

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Published on: January 11, 2020

Late-Stage Fluorination: From Fundamentals to Application.

Michael G Campbell¹, Tobias Ritter¹

¹Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

Organic Process Research & Development

|April 4, 2015

Summary

This review covers late-stage fluorination methods for small molecules, emphasizing practical industrial applications. We critically assess current developments for their real-world utility and potential.

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Published on: January 11, 2020

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes

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A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence FUEL

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Published on: May 23, 2014

Area of Science:

Organic Chemistry
Medicinal Chemistry
Chemical Synthesis

Background:

Late-stage functionalization is crucial for drug discovery and development.
Introducing fluorine and fluorinated groups can significantly alter molecular properties.
Efficient methods for late-stage fluorination are highly sought after in the pharmaceutical industry.

Approach:

This work reviews laboratory findings on late-stage introduction of fluorine.
Focuses on practical developments with potential industrial applications.
Critically evaluates methods for their current utility and future prospects.

Key Points:

Highlights successful late-stage fluorination strategies.
Discusses the incorporation of fluorinated functional groups into small molecules.
Assesses the scalability and applicability of reviewed methods for industrial use.

Conclusions:

Several practical developments in late-stage fluorination show promise for industrial applications.
Further critical evaluation is needed for methods not yet meeting practical use standards.
This review provides insights into advancing fluorination chemistry for small molecule synthesis.