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Mitral Stenosis I: Introduction

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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Mitral Regurgitation I: Introduction

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...

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Related Experiment Video

Updated: Apr 15, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Rituximab induced left bundle branch block.

Mujeeb Sheikh¹, Ankush Moza¹, Blair P Grubb¹

¹Department of Medicine, Division of Cardiovascular Medicine, University of Toledo Medical Center, Toledo, Ohio, U.S.A.

Heart Views : the Official Journal of the Gulf Heart Association

|April 4, 2015

Summary

This summary is machine-generated.

Rituximab therapy, used for Wegener's vasculitis, can rarely cause cardiac issues. This report details the first observed case of new-onset left bundle branch block following rituximab treatment.

Keywords:

Arrhythmia bundle branch block rituximab

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Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

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Published on: February 1, 2022

Area of Science:

Immunology
Cardiology
Rheumatology

Background:

Rituximab is a monoclonal antibody targeting CD20, widely used in autoimmune diseases.
Potential adverse events include infusion reactions and cardiac arrhythmias.
Wegener's granulomatosis (now Granulomatosis with Polyangiitis) is a systemic vasculitis.

Observation:

A patient undergoing rituximab therapy for Wegener's vasculitis developed a cardiac complication.
The complication manifested as a new onset left bundle branch block (LBBB).

Findings:

This represents the first documented instance of LBBB occurring after rituximab administration.
The event highlights a potential, albeit rare, cardiac adverse effect of rituximab therapy.

Implications:

Clinicians should be aware of the potential for new-onset LBBB in patients receiving rituximab.
Further investigation may be warranted to understand the mechanism and incidence of this specific cardiac event.
This case adds to the spectrum of cardiovascular risks associated with rituximab therapy.