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Amisulpride augmentation for clozapine-refractory positive symptoms: additional benefit in reducing hypersialorrhea
Fabiani Bogorni1, Frederico Fernandes Moreira1, Eduardo Mylius Pimentel1
1Programa de Residência Médica em Psiquiatria do Instituto de Psiquiatria de Santa Catarina (IPQ/SC), 88.123-300 São José, SC, Brazil.
Abstract:
One-third to half of patients taking clozapine suffer from refractory symptoms despite adequate treatment. Among other adverse effects, clozapine-induced hypersalivation (CIH) occurs in approximately half of all patients. This is a case of a 30-year-old male with refractory schizophrenia; in this patient, the remission of residual positive symptoms, as well as the reduction of CIH, was achieved by treatment with clozapine augmented with amisulpride.
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