Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

55.8K
Overview
55.8K
Overview of the Vascular System01:20

Overview of the Vascular System

3.8K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.8K
Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

21.4K
Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
21.4K
Physiological Barriers01:25

Physiological Barriers

5.8K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.8K
Characteristics and Functions of Blood01:26

Characteristics and Functions of Blood

12.6K
Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...
12.6K
Capillaries and Their Types01:20

Capillaries and Their Types

10.4K
Capillaries, a crucial constituent of the circulatory system, are diminutive vessels with a diameter between 5–10 micrometers, accommodating perfusion to the tissues through the phenomenon known as microcirculation. Through their permeable walls, consisting of an endothelial layer ensconced by a basement membrane and sporadically dispersed smooth muscle fibers, the exchange of substances between the blood and the interstitial fluid becomes plausible. Variance in wall composition exists,...
10.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systemic alpha-1 adrenergic receptor inhibition reduces sperm damage in adult and aging spontaneously hypertensive rats.

Scientific reports·2024
Same author

Effect of coronaviruses on blood vessel permeability: potential therapeutic targets.

Therapeutic advances in respiratory disease·2023
Same author

Editorial: Interplay Between Autophagy and Metabolic Syndrome: Causes, Consequences and Therapeutic Challenges.

Frontiers in cell and developmental biology·2021
Same author

Gold nanoparticles reduce inflammation in cerebral microvessels of mice with sepsis.

Journal of nanobiotechnology·2021
Same author

Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease.

Blood·2021
Same author

Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation.

Circulation·2019
Same journal

Blood-brain barrier permeability in diffuse large B-Cell lymphoma: associations with established risk factors for CNS relapse.

Tissue barriers·2026
Same journal

Developmental maturation of intestinal junctional complexes in preterm infants.

Tissue barriers·2026
Same journal

Inflammation and epidermal barrier integrity, decline, and restoration: It's time to rouse the "guardians at the gate".

Tissue barriers·2026
Same journal

Involvement of vimentin intermediate filaments in overcoming tissue barriers during cancer cell dissemination.

Tissue barriers·2026
Same journal

Mutational signatures in blood-brain barrier: mechanisms, computational insights, and clinical applications in precision oncology.

Tissue barriers·2026
Same journal

Integrated transcriptomic and functional characterization of Claudin-1 reveals its oncogenic and immunomodulatory roles in pancreatic ductal adenocarcinoma.

Tissue barriers·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors
09:38

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors

Published on: September 22, 2023

1.2K

Blood cells and endothelial barrier function.

Stephen F Rodrigues1, D Neil Granger2

  • 1Department of Clinical and Toxicological Analyses; School of Pharmaceutical Sciences; University of Sao Paulo ; Sao Paulo, Brazil.

Tissue Barriers
|April 4, 2015
PubMed
Summary
This summary is machine-generated.

Endothelial barrier dysfunction, crucial for fluid balance, is implicated in diseases like stroke and cancer. This review explores how blood cells and mediators impact this barrier, highlighting therapeutic targets.

Keywords:
AJ, Adherens junctionsANG-1, Angiopoietin 1AQP, AquaporinsBBB, blood brain barrierCNS, Central nervous systemCOPD, Chronic obstructive pulmonary diseaseEAE, Experimental autoimmune encephalomyelitisEPAC1, Exchange protein activated by cyclic AMPERK1/2, Extracellular signal-regulated kinases 1 and 2Endothelial barrierFA, Focal adhesionsFAK, focal adhesion tyrosine kinaseFoxO1, Forkhead box O1GAG, GlycosaminoglycansGDNF, Glial cell-derived neurotrophic factorGJ, Gap junctionsGPCR, G-protein coupled receptorsGTPase, Guanosine 5'-triphosphataseHMGB-1, High mobility group box 1HRAS, Harvey rat sarcoma viral oncogene homologICAM-1, Intercellular adhesion molecule 1IL-1β, Interleukin 1 betaIP3, Inositol 1,4,5-triphosphateJAM, Junctional adhesion moleculesMEK, Mitogen-activated protein kinase kinaseMLC, Myosin light chainMLCK, Myosin light-chain kinaseMMP, Matrix metalloproteinasesNO, Nitric oxideOSM, Oncostatin MPAF, Platelet activating factorPDE, PhosphodiesterasePKA, Protein kinase APNA, Platelet-neutrophil aggregatesROS, Reactive oxygen speciesRac1, Ras-related C3 botulinum toxin substrate 1Rap1, Ras-related protein 1RhoA, Ras homolog gene family, member AS1P, Sphingosine-1-phosphateSCID, Severe combined immunodeficientSOCS-3, Suppressors of cytokine signaling 3Shp-2, Src homology 2 domain-containing phosphatase 2Src, Sarcoma family of protein kinasesTEER, Transendothelial electrical resistanceTGF-beta1, Transforming growth factor-beta1TJ, Tight junctionsTNF-, Tumor necrosis factor alphaVCAM-1, Vascular cell adhesion molecule 1VE, Vascular endothelialVE-PTP, Vascular endothelial receptor protein tyrosine phosphataseVEGF, Vascular endothelial growth factorVVO, Vesiculo-vacuolar organelleZO, Zonula occludenscAMP, 3'-5'-cyclic adenosine monophosphateerythrocytesleukocytespSrc, Phosphorylated Srcplateletsvascular permeability

More Related Videos

Author Spotlight: Applications of TEER Detection to Assess Cell Barrier Integrity
09:03

Author Spotlight: Applications of TEER Detection to Assess Cell Barrier Integrity

Published on: September 29, 2023

5.3K
Isolation of Primary Murine Brain Microvascular Endothelial Cells
08:14

Isolation of Primary Murine Brain Microvascular Endothelial Cells

Published on: November 14, 2014

34.3K

Related Experiment Videos

Last Updated: Apr 15, 2026

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors
09:38

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors

Published on: September 22, 2023

1.2K
Author Spotlight: Applications of TEER Detection to Assess Cell Barrier Integrity
09:03

Author Spotlight: Applications of TEER Detection to Assess Cell Barrier Integrity

Published on: September 29, 2023

5.3K
Isolation of Primary Murine Brain Microvascular Endothelial Cells
08:14

Isolation of Primary Murine Brain Microvascular Endothelial Cells

Published on: November 14, 2014

34.3K

Area of Science:

  • Cardiovascular Biology
  • Cell Biology
  • Pathophysiology

Background:

  • Endothelial barrier integrity is vital for regulating fluid and protein exchange between blood and tissues.
  • Impaired endothelial barrier function contributes to various diseases, including edema, stroke, sepsis, and cancer.
  • Mediators released by resident and blood cells can disrupt endothelial junctions and cytoskeleton, compromising barrier function.

Purpose of the Study:

  • To review the role of blood-borne cells (neutrophils, lymphocytes, monocytes, platelets) in regulating endothelial barrier function.
  • To discuss the mechanisms by which mediators like reactive oxygen species and growth factors affect endothelial barrier integrity.
  • To identify potential therapeutic targets for conditions associated with endothelial barrier dysfunction.

Main Methods:

  • Literature review of studies investigating endothelial barrier function.
  • Analysis of the roles of specific blood cells and soluble mediators.
  • Examination of molecular mechanisms altering endothelial cell junctions and cytoskeleton.

Main Results:

  • Blood-borne cells significantly influence endothelial barrier function in both health and disease.
  • Various mediators, including ROS, proteases, Oncostatin M, and VEGF, are key players in endothelial barrier failure.
  • Dysfunctional endothelial barriers are linked to pathological conditions such as pulmonary edema, ischemic stroke, and cancer.

Conclusions:

  • Understanding the interplay between blood cells, mediators, and endothelial cells is crucial for addressing barrier dysfunction.
  • Targeting specific cellular and molecular pathways offers potential for novel therapeutic strategies.
  • Further research into endothelial barrier regulation can lead to improved treatments for a range of diseases.