Giant solitary trichoepithelioma

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Giant solitary trichoepithelioma is a rare trichogenic tumor.
• Limited information exists on its genesis, clinical profile, behavior, and management.
• Only 18 cases have been reported globally.

Purpose of the Study:

• To provide insight into the rare giant solitary trichoepithelioma.
• To consolidate existing knowledge on this adnexal tumor.
• To guide clinical understanding and management.

Main Methods:

• Comprehensive literature search across PubMed, DOAJ, HINARI, and Google databases.
• Inclusion of standard dermatology texts.
• Review of indexed literature for relevant case reports and studies.

Main Results:

• Giant solitary trichoepithelioma is a rare tumor with local recurrence potential.
• It commonly affects older individuals but can occur at any age.
• Clinically and histologically resembles basal cell carcinoma and other adnexal tumors.
• CD10, CD34, and PHLDA1 are useful diagnostic markers; p75NTR is not.
• Surgical excision is the primary treatment modality.

Conclusions:

• Giant solitary trichoepithelioma requires careful diagnosis due to its similarity to other skin tumors.
• Surgical excision is effective but necessitates regular follow-up.
• Potential for recurrence and transformation into basal cell carcinoma warrants vigilant monitoring.