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Smoking and Intracranial Aneurysm Morphology
Allen L Ho1, Ning Lin, Kai U Frerichs
1*Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts; ‡Harvard Medical School, Boston, Massachusetts; §Department of Neurological Surgery, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York.
Neurosurgery
|April 4, 2015
Summary
Smoking is linked to distinct cerebral aneurysm characteristics, including multiple aneurysms and larger vessel involvement. These findings may explain smoking
Area of Science:
- Neurosurgery
- Radiology
- Vascular Biology
Background:
- Smoking is a significant risk factor for aneurysm formation and rupture.
- Aneurysm morphology, beyond size, influences rupture risk through hemodynamic effects.
Purpose of the Study:
- To investigate differences in aneurysm morphology between smokers and nonsmokers.
- To determine how these morphological changes impact aneurysm formation and rupture.
Main Methods:
- 3D aneurysm models were created from computed tomography angiograms using Slicer software.
- Statistical analyses examined associations between smoking status and aneurysm morphology.
Main Results:
- Current smokers had aneurysms associated with multiple aneurysms (OR: 2.15), larger daughter vessel diameters (OR: 3.13), larger size ratio (OR: 1.78), and basilar apex location (OR: 6.26).
- Analysis included 199 cerebral aneurysms (102 never smokers, 97 current smokers) from 2005-2013.
Conclusions:
- Morphological differences in aneurysms between smokers and nonsmokers may clarify smoking's role in aneurysm development and rupture.
- Identified morphological aspects linked to smoking provide a basis for understanding increased rupture risk.
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