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Updated: Aug 14, 2026

A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants
Published on: May 1, 2013
Techniques and technologies to maximize mucosal exposure
Leon M G Moons1, Ian M Gralnek2, Peter D Siersema1
1Department Gastroenterology and Hepatology, University Medical Center Utrecht, Heidelberglaan 100, 3508CH Zeist, Utrecht, The Netherlands.
Abstract:
Performing high-quality colonoscopy is one of the important goals of gastroenterology practices and requires achieving a high level of bowel cleansing, performing good and safe polypectomy, and detecting all polyps present in the colon. This article summarizes currently available techniques and technologies to maximize mucosal visualization. Several maneuvers can be applied during insertion and withdrawal of the colonoscope to optimize mucosal visualization and decrease the number of missed polyps. Newly developed technologies support the endoscopist in the detection of polyps. Each technique is reviewed, with emphasis on the impact on colorectal polyp detection.

