Gigantiform cementoma of the jaws

Fibro-osseous cemental lesions of the jaw remain a controversial area of bone/cementum pathology. This article describes the clinicopathological features of 28 lesions classified as gigantiform cementoma. Black women are affected more frequently than other race and sex groups, with a peak frequency of occurrence in the fourth and fifth decades. The posterior mandible is preferentially affected and unifocal lesions (67.9%) occur more frequently than multifocal lesions (32.1%). Dull pain and a centrifugal size increase are the most prevalent presenting symptoms. Of 28 cases with parental and sibling clinical information, there were no cases which exhibited an autosomal dominant genetic association. The pathogenesis of this lesion in relation to other cemental lesions of the jaws, as well as the clinical management of cemental jaw lesions, is discussed.