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Mapping Dysfunctional Protein-Protein Interactions in Disease
Published on: October 24, 2025
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Recent positive selection has acted on genes encoding proteins with more interactions within the whole human
Pierre Luisi1, David Alvarez-Ponce2, Marc Pybus3
1Institute of Evolutionary Biology, Universitat Pompeu Fabra-CSIC, CEXS-UPF-PRBB, Barcelona, Catalonia, Spain jaume.bertranpetit@upf.edu hafid.laayouni@upf.edu.
Genome Biology and Evolution
|April 4, 2015
Summary
Genes
Area of Science:
- Genomics and evolutionary biology.
Background:
- Genes exhibit varying susceptibility to adaptive evolution.
- Genomic factors influencing adaptability are not fully understood.
- Gene function within molecular networks suggests differential selective pressures.
Purpose of the Study:
- To investigate how positive selection distributes across molecular networks.
- To explore the relationship between gene network position and adaptive evolution.
Main Methods:
- Inferred positive selection using comparative genomics (10 mammalian genomes).
- Inferred positive selection using population genetics (270 human genomes).
- Analyzed gene network centrality in relation to selection signals.
Main Results:
- Genes with lower network centrality showed positive selection in divergence data.
- Genes with higher network centrality showed positive selection in polymorphism data.
- The impact of adaptive evolution on genes depends on selection mode and evolutionary timescale.
Conclusions:
- Network centrality's role in adaptive evolution is complex and context-dependent.
- Divergence and polymorphism data reveal different patterns of selection on gene networks.
- Understanding gene network architecture is crucial for studying evolutionary adaptation.
Keywords:
humansmammalsnatural selectionphysical protein interactionpositive selectionprotein interaction networkMore Related Videos
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